LEMS is also autoimmune in nature and results from an antibody attack on the nerves blocking their ability to secrete acetylcholine. LEMS is a very rare disease and is characterized by muscle weakness of the limbs.
Neonatoccurs when there is a temporary transfer of MG from a woman with autoimmune disease to her newborn child. A poor suck, breathing difficulties, feeble cry and weak movements may be noted in the infant after birth. Return of muscle strength occurs spontaneously, usually two to three weeks after birth.
Although most MG is autoimmune there are other forms of MG which are not. CMS include a rare, genetically based group of disorders of neuromuscular transmission usually evident at birth, or shortly after, that are clinically similar to autoimmune MG but without immunologic origin.
